Thursday, August 2, 2007

Laboratory Instrumentation - Biotechnology

Abbott Diagnostics Division UK Supplying the laboratory and medical diagnostics industries.
Aldrich Chemical Searchable catalog.
Alfa Aesar International manufacturer and supplier of chemicals, materials and accessories for research, development and production applications.
Amresco High purity chemicals.
Analytical Spectral Devices Portable spectrometers, spectrophotometers, spectroradiometers, and near infrared analyzers.
Animal Technologies A biological raw material supplier.
Annovis A specialty chemicals company that is focused the "mimetics" field.
Anthos Analytical Apparatus Luminometers, flurometers and related research equipment.
Ardus Medical Sale and rental of pre-owned infusion delivery devices, defibrillators, pulse oximeters, SCD's, and related disposables.
Ascent Scientific Chemistry services for pharmaceutical, agrochemical, life science and chemistry-related industries; synthetic chemistry, ligands and biochemicals, chemical research and development, chemical and 5S consultancy, and analytical and purification services.
ASINEX Organic samples for screening in pharmaceutical and agricultural research.
Avecia Fine and specialty chemicals; organic chemistry, biological and polymer sciences, and process technology.

Biotechnology Directory - Products

A.G. Scientific Supplying innovative biochemicals for scientific research in such areas as free radical biology, apoptosis, neuroscience, and signal transduction.
Abi Advanced Biotechnologies Inc. manufacture, development, and/or supply of critical, value-added products and services for the research, diagnosis, monitoring, and treatment of significant viral infectious diseases.
Active Motif Molecular biology research products, including mRNA isolation kits .
Addgene A non-profit organization dedicated to promoting sharing of plasmid constructs described in published literature. Addgene stores original plasmid samples submitted by scientists and distributes them for use in advancing life science research.
ADIATEC Diagnostics and biotechnologies, including rapid immuno-chromatographic tests, one-step immunoassay strip for rapid determination of human serum total IgE, and rapid, one-step, sensitive and highly specific determination of the isotype of mouse monoclonal antibody.
Advanced Biotechnologies Molecular biology catalog and ordering.
Alkami Biosystems A biological software (bioinformatics) and consulting company. PCR resources for the molecular biologist.
AMBETRONICS Laboratory instrumentation. (India)
Ambion Development and supply of RNA-based life science research and molecular biology products; specializes in the development of products for stabilizing, synthesizing, handling, isolating, storing, detecting and measuring RNA.
Americas VTA Supplier of vacuum distillation equipment, providing short path, thin film and wiped film evaporators as well as process development, laboratory and pilot plants and complete turnkey production plants.
Analiza Technologies in Automated analysis of pharmacokinetic (ADME) properties of drug candidates, rapid characterization of structural aspects of biomolecules, and purification, formulation, and analysis of protein therapeutics.
Apostain, Inc. Detection of apoptic cells with monoclonal antibody to single-stranded DNA.
arrayit.com DNA custom microarray services, advanced microarray products, chemical distribution.
ASDI BioSciences High Throughput Screening samples and services.
Asper Biotech Coated glass microarray slides, printed slides, 4 laser microarray scanner, also high througouput genotyping, bioinformatics services.
Assay Designs Immunoassay and DNA/RNA probe diagnostics for the FDA-regulated clinical hospital market; chemiluminescent and bioluminescent systems for the measurement of low concentration analytes.
AssayMetrics Fluorescence lifetime assay technologies: dyes, assays, software and consultancy.
AthenaES Athena Enzyme Systems, research products ranging from expression media to protein refolding reagents to serum-free cell culture products.
Attana Instruments enable studies of molecular interactions (antibody/antigen) in real-time without the need of labels, resulting in faster and more cost effective research.
Aurora Fine Chemicals A chemistry-based company engaged in laboratory scale organic synthesis, drug and chemical product research, and chemical product sales; synthesize novel and rare organic compounds in the scale ranging from milligram to multi-kilogram quantities; building blocks for combinatorial chemistry and intermediates for organic synthetic chemistry; online, structure-based catalog.
Aurora Photonics Small-footprint/portable cost effective microarray imagers combining low energy illumination technology with ultra-fast CCD detection and optional thermal slide control for applications in all settings.
BaseStation DNA fragment analyzer.
BIA Separations CIM Convective Interaction Media chromatographic supports for fast HPLC and LC separation and purification.
Biacore AB Development, manufacture and marketing of products to detect and monitor biomolecular binding.
BioAutomation MerMade DNA/RNA oligo synthesizer.
Biocell Laboratories A primary manufacturer of Class I, II and III medical devices and blood plasma components.
BioChain Institute Integrated tools for drug target validation and diagnostic assay development. More than 5,000 ready-to-use products, including reagents and kits for extraction, purification, and analysis, as well as custom designed products and services
BioDesign of New York Innovative products for the biological researcher.
BioForce Nanosciences Developer of ultra-miniaturized nanoarray technologies for the solid-state, high-throughput analysis of molecular systems.
BIOgate Life science portal for Israel.
BioNobile Oy Magnetic bioseparation systems for a wide range of applications, including nucleic acids purification, protein purification, and cell separation.
Bio-Rad Laboratories Life science research products, clinical diagnostics and research instruments; KnowItAll Informatics for ADME/Tox.
Bioron Basic and advanced products for molecular biology.
BioTX Automation Design and construction of complex mechanical components; automated liquid handling for the life science laboratory; USGRD database of federal grants awarded.
Bioxel A biopharmaceutical company focused on the manufacture and distribution of taxane pharmaceutical ingredients including paclitaxel, docetaxel, 9-DHB and 10-DAB.
Caliper Technologies Microfluidic lab-on-a-chip technology; designs, manufactures, and commercializes LabChip devices and systems.
Celartia Cell Culture Manufacturer and distributor of the Petaka cell culture device.
Cell Essentials Services and products to facilitate research, including the production of custom hybridomas and related services as well as all aspects of cell culture.
Cell Signalling Technology Drug discovery tools; signal transduction reference material; pathways.
cellix An instrumentation company providing microfluidic technology based solutions in the areas of drug discovery, diagnostics and medical research.
Cheap Tubes Supplying the nanotechnology research and industrial community with the carbon nanotubes (CNTs), whether to an independent researcher or a large-volume user of CNTs.
CLONTECH Labs PCR kits, GFP expression products.
Crist Instrument Research equipment including primate chairs, animal handling devices, microdrives, reward systems, implant and alignment equipment, stereotaxics and custom lab design and installations.
CSPS Software, chemicals and instrumentation for combinatorial chemistry.
CytoShop On-line marketing of cytokines, antibodies and growth factors.
CytoSignal Research products on-line catalog.
Diaclone Research and diagnostic products; clinical mAb production.
DIGITANA Cell culture and antibody technologies.
Display Systems Biotechnology Gene expression and regulation.
DNA Technologies Products and services for genomics and proteomics researchers
DNA Technologies Products and services that expedite and enhance scientific research and collaboration in genomics and proteomics, including real time PCR, DNA sequencing, oligo synthesis, plasmid manufacturing.
DNAFORM Transcriptome Services, full-length cDNA cloning, cone distribution, reagents in molecular biology.
DSM Pharmaceutical Products A wide variety of products for biotechnology and the life sciences, including vitamines and fine chemicals.
Emerald BioSystems Laboratory automation, software tools, and consumable products for gene to protein crystal structure research.
Enamine Provider of custom chemistry services and screening libraries for pre-clinical drug discovery and agro chemistry worldwide; over 500,000 screening compounds in-stock; 15,000 proprietary and 9,000 acquired building blocks; validated virtual chemical space (REAL Database) of over 12 million compounds; molecular modeling services. Japan.
Epicentre Technologies Tools for DNA sequencing and analysis of gene functions.
Erie Sceintific High-density arrays, cover glasses, micriarray substrates.
Exclusive Chemistry Custom synthesis of organic compounds and projects involving contract researches; also building blocks for combinatorial chemistry and samples for screening.
ExpressOn Biosystems Antisense and siRNA design.
EZQuant Image analysis tools for biological use.
FEI Company Systems and software for nanotechnology and nanobiology research.
Fermentek Research, development and manufacture of biologically active, natural products isolated from microorganisms as well as from other natural sources such as plant and algea.
Finnzymes Products for PCR and molecular biology.
Fluidigm Develop, manufacture, and distribute systems composed of IFCs (integrated fluidics circuits), instrumentation, and consumables.
Fluoresentric Real-time PCR assay design and optimization.
G-Biosciences and Genotech Providing protein research products including those for protein sample preparation, protein assays, electrophoresis, gel stains, protein labeling and protease-protease inhibitor systems; also products for DNA/RNA purification-isolation and yeast-E.coli research systems
Gene Therapy Systems Designs, develops and commercializes gene therapy products along with other molecular biological reagents for scientists specializing in gene therapy research.
GeneMachines Genomics and robotics products for DNA purification, oligo synthesis, colony picking, micro arraying, etc.
GeneTex Developer, manufacturer and supplier of monoclonal and polyclonal antibodies and research reagents.
Genetic Microsystems Systems for producing and scanning microscope slides containing thousands of DNA samples represented as individual elements in identifiable locations.
Genetix Automated colony pickers, gridders, replicators, rearrayers, microarrayers, liquid handling systems and related consumables for the pharmaceutical, genomic and bioresearch industries.
GenHunter Manufacturing and marketing of differential display reagent technologies.
Genisphere Array detection kits.
Geno Technology Research tools for cell biology.
GenoSpectra RNA quantitation technology; develops and commercializes Parallel Quantitative Biology, (PQB) products for life science research
Gentest Produces and distributes cell lines and microsomes containing cDNA- expressed cytochrome P450s and other drug metabolizing enzymes, inhibitory and Western blotting antibodies against P450s, substrates, inhibitors and metabolite standards for drug metabolism research.
Gentra Systems Developing and selling nucleic acid purification products that improve the speed, ease-of-use and quality of sample preparation for clinical and research applications.
Gibco BRL Life Technologies Producer of GIBCO BRL Products.
Glen Research Products for DNA and RNA research.
Glycosan BioSystems Develops, manufactures, and markets formulations of a hyaluronan-based synthetic extracellular matrix (synthetic ECM) for general 3-D cell culture. Applications: tumor xenograft, chemoinvasion, and angiogenesis assays as well as stem cell cultivation and tissue engineering
Glycosynth Manufacturer of high purity chromogenic and fluorogenic substrates for use in diagnostics, microbiology, molecular biology and medical research.
Grace Bio-Labs Technology for marker discovery and diagnostic applications in molecular pathology.
greiner bio-one Preanalytics division manufactures preanalytical products used to extract and further process human samples for the purposes of analysis; BioScience develops and sells products for the diagnostics industry, biotechnology and research.
Groovy Blue Genes Biotech Canadian antibody distributor for BioLegend, BioVision, ProSci, Biotrend, INNOVEX, ProSpecTany, Mubio & PhosphoSolutions.
Guava Technologies Develops, manufactures and markets integrated cellular analysis systems for the life science researcher’s benchtop.
Guava Technologies Benchtop micro-volume cell analysis.
htrf Cisbio's homogeneous time resolved flourescence site.
IBIS Technologies Products for biomolecular interaction sensing based on surface plasmon resonance (SPR) technology.
IBT Immunological and Biochemical Test systems GmbH. Oligonucleotide Probe Kits for insulin-like Growth Factors (IGF´s), IGF-Binding Proteins (IGFBP´s), IGF-receptors and Insulin-like Growth Factor Binding Protein-Related Proteins (IGFBP-rP´s) of a wide range of species.
Idaho Technology Machines for pathogen identification and DNA analysis; including DNA amplification, real-time PCR, Hi-Res Melting, mutation detection and genotyping; products include the R.A.P.I.D. and RAZOR Systems and the LightScanner, HR-1 and RapidCycler Instruments along with freeze-dried reagents and DNA/RNA purification and test kits. IT BioChem offers a complete list of probes, primers and melting dyes for real-time PCR instruments.
IGEN Detection and quantitation of bi-molecular interactions.
Imgenex RetroMax Retroviral Expression System; ReadyGenes; INSTA-Blot Western blots.
International Specialty Products Excipients and fine chemicals.
IZOTOP Radiochemical, radiopharmaceuticals, immunoassay kits, molecular biology, custom synthesis, radiation techniques.
jpt Supplier of innovative peptide based products and services for the biomedical research worldwide
KC Biotech Products for cell culture systems, particularly for serum-free cell culture.
KPL Protein detection reagents such as secounday antibodies and exceptional substrates for use in ELISA and Western Blotting; over 500 immunoreagents
Life Sciences Dye-Doped Silica Nanoparticles (DDSNP) for use as reporters in improved bioanalytic systems.
Lomir Biomedical Manufacturer of equipment for pre-clinical investigations, primarily intravenous infusion and dermal applications.
Luminex LabMAP technology measures multiple analytes simultaneously in a single reaction vessel.
Luminometer Grants Program donations of luminometers for life science research.
Lynx Therapeutics Applying genomics, genetics, and proteomics technologies to the discovery and development efforts in the pharmaceutical and agricultural biotechnology industries.
MBI Fermentas Providing a full line of products for molecular biology research including restriction endonucleases and products for PCR.
MBI Fermentas Providing a full line of products for molecular biology research including restriction endonucleases and products for PCR.
Mergen Ltd. Focuses on the development and sales of DNA microarray products and services.
Metkinen Chemistry Reagents for DNA and RNA synthesis, Truly Universal solid support, trimer (codon) phosphoramidites, purine nucleoside analogs and FAM Phosphoramidities.
MoBiTec Molecular biology technologies.
Mologen GmbH Vectors for gene therapy and genetic vaccination.
MP Biomedicals (Formerly ICN and Qbiogene) provide a wide range of products (+55.000) in the following ranges : Biochemicals, radiochemicals, immunobiologicals, cell biology media and reagents, molecular biology reagents, transfection, genedelivery, peptides and protein products, neuroscience/signal transduction, electrophoresis.
MRC (Molecular Research Center) Develops and manufactures innovative products for the isolation and analysis of RNA and DNA.
MWG Biotech Nonradioactive DNA sequencing and other equipment and services.
New England Biolabs On-line catalog of molecular biology and signal transduction products.
Nimbus Biotechnology Products for bioseparation and for the automated determination of membrane binding constants (High Throughput Screening) of pharmacological relevant molecules.
Otava Fine organic chemicals including unique building blocks for combinatorial organic synthesis; compound libraries for screening and custom synthesis service.
PanVera Products for drug discovery and life science research, including recombinant proteins and contract services.
Peakdale Drug discovery, novel chemicals, custom synthesis.
Polium Specializes in biocatalysts, small molecule catalysts, and chiral technologies for the biochemical industry.
PrimeSyn Lab Custom DNA/RNAi synthesis and purification; Oligonucleotides and ASRs; analytical lab services.
Professional Biotech Diagnostic solution provider in Life Sciences, including real-time PCR. (India)
Proligo Custom DNA and RNA oligonucleotides, DNA and RNA synthesis reagents, design services for siRNA, Q.PCR probes and oligos.
ProQinase Tools and tests for protein kinase technology.
Proteomichip Tools and technologies developer for drug discovery and disease diagnostic. Differential Proteomic Panning, DNA methylation profiling, improved DNA array hybridization technologies are available for licensing.
QTL Biosystems Amplification technologies for bioassays.
QuantumDot develops and markets solutions for biomolecular detection employing quantum dot particles, tiny semiconductor crystals that emit light brightly in a range of sharp colors.
Radicon Digital Gel Documentation and Analysis System (DGelDAS).
Retrogen Provider of DNA sequencing, gene synthesis, mutagenesis, SNP discovery, oligos and purification kits.
RNA interference portal Jobs, news, recent literature, lab registry etc... updated daily.
RNAture Providing technology platforms and automated tools for gene expression and functional genomics analysis to the research and pharmaceutical communities.
SAFC Biosciences Developing, manufacturing and marketing cell culture reagents and services.
SBH Sciences Provider of process development solutions and cytokine bioassay services
SCHOTT North America Pharmaceutical packaging; SCHOTT Nexterion coated and uncoated glass substrates for DNA and protein microarrays.
Shenandoah Biotechnology Cytokines, chemokines, interleukins, growth factors, hormones and more; specializes in providing E. coli derived recombinant human, murine and rat cytokines, growth factors, ligands, receptors, and enzymes.
Sigma-Aldrich Materials for biological research.
StemCell Technologies Specialized media and cell separation products, cytokines, antibodies, tissue culture reagents, as well as services including contract assays, proficiency testing, and training.
Sunrise Scientific Products Magnetic separation reagents, yeast growth media, lab tools, and custom kits.
Sunwincn.com Bulk intermediates,feed additives, chemical raw material,electroplate, printing and dyeing.
Taconic Animal models, specialized breeding services, cGMP Monoclonal Antibody production, GLP DNA assays.
Tetra Link Instrumentation for molecular biology and immunology.
The Great American Gene Company Custom PCR and sequencing primers
Thermo Electron Clinical chemistry reagents; cell culture media and sera for cell line growth. Outside North America offers automated clinical chemistry analyzers with a wide range of optimized system reagents. Instrumentation for drug discovery.
Thermo Fisher Scientific Analytical instruments.
ThermoQuest Protein analysis systems for proteomics.
Transgenomic Turnkey solutions for the analysis of nucleic acids, proteins and carbohydrates.
Turner BioSystems Luminometers and fluorometers.
Ventana Medical Systems Molecular Discovery Systems (MDS) division offers solutions for slide-based applications including immunohistochemistry, in situ hybridization, and microarrays.
Vitas-M Laboratory Organic drug like compounds for High Throughput Screening; custom synthesis service to the pharmaceutical and biotech industry
Vivascience Tools for protein research, including Vivapure ion exchangers.
Wave Biotech Developing disposable bioprocess equipment for operations traditionally requiring stainless-steel tanks and piping.
www.nutricyte.com Specializes in media, buffers, reagents, antibiotics and customized products for cell culture. Laboratory services include cell banking, cell adaption, tissue culture and cell based assays.
xeotron Made-to-order microarrays from on-line Virtual Probe Libraries (VPL), Microfluidic Station, and validated labeling and buffer kits.
Yield Pharma Rare amino acids and other compounds.

Classic Biotech Stories

Bacterial Mutations - 1943 Luria and Delbruck hit the jackpot in studying bacteria for viral resistance
Birds Do It, Bees Do It - 1946 Lederberg and Tatum discover bacterial mating and phage recombinations
Experiments that Inspire - 1952 Hershey and Chase conduct experiments showing DNA was the hereditary material
Legacies - Transformation and DNA - 1920 Griffith discovers that bacteria can change from one form to another
Lwoff's Pathways - Viral Replication - 1950 Lwoff studies viral lysogenic viral replication patterns
The March of Heredity - 1943 Hammerling searches for the part of the cell directing physical appearances
Of Mice and Men - 1980 discovery of severe combined immunodeficient mice - mutant mice
Mutant Gene Predicts Heart Disease - 1994 Japanese researchers identify the gene the encodes for angiotensin converting enzyme (ACE)
The One Gene/One Enzyme Hypothesis - 1941 Beadle and Tatum set out to prove the connection between genes and enzymes
Rhizobium Meliloti Field Tests - 1994 reports on a test to increase crop production by the addition of extra copies of a nitrogen fixation gene and a gene involved in energy transport
The Slow Death of Spontaneous Generation (1668-1859) - story of how spontaneous generation was finally laid to rest
Stories from the Scientists (teacher resources & student activities).

Biotech Briefs

The Beauty of Mutations - errors in the genetic code and what they might mean
Crossing-over: Genetic Recombination - why no two people look alike
Dogma, DNA, and Enzymes - reviews that DNA makes RNA makes protein, the central dogma of molecular biology
DNA Bends to Bind - using scanning force microscopy to study protein synthesis
How RFLPs Can Help Find a Faulty Gene - the role of restriction enzymes in determining genetic diseases
Into the Looking Glass - hereditary material is bound on chromosomes
Monoclonal Antibody Technology - The Basics - concise description of the immune response and the uses of antibody production in treating disease
Polymerase Chain Reaction - From Simple Ideas - a method for analyzing and characterizing minute amounts of DNA
Polymerase Chain Reaction - Xeroxing DNA - a bacterium from Yellowstone Park provides a molecule that helps scientists produce millions of copies of DNA in a matter of hours
Reading the Messages in Genes - brief review of genetic code to protein synthesis
Recombination Up Close - story of genetic engineering: technology and techniques
The Search for DNA - review of the key events leading to the structure of the DNA molecule
Speaking the Language of Recombinant DNA - an analogy between the function of the DNA molecule and the rules of grammar for a language
The YACs are Here! - yeast artificial chromosomes (YACs) enable scientists to borrow the DNA duplication machinery of cells, including human cells

Biotechnology

Biotechnology in one form or another has flourished since prehistoric times. When the first human beings realized that they could plant their own crops and breed their own animals, they learned to use biotechnology. The discovery that fruit juices fermented into wine, or that milk could be converted into cheese or yogurt, or that beer could be made by fermenting solutions of malt and hops began the study of biotechnology. When the first bakers found that they could make a soft, spongy bread rather than a firm, thin cracker, they were acting as fledgling biotechnologists. The first animal breeders, realizing that different physical traits could be either magnified or lost by mating appropriate pairs of animals, engaged in the manipulations of biotechnology.

What then is biotechnology? The term brings to mind many different things. Some think of developing new types of animals. Others dream of almost unlimited sources of human therapeutic drugs. Still others envision the possibility of growing crops that are more nutritious and naturally pest-resistant to feed a rapidly growing world population. This question elicits almost as many first-thought responses as there are people to whom the question can be posed.
In its purest form, the term "biotechnology" refers to the use of living organisms or their products to modify human health and the human environment. Prehistoric biotechnologists did this as they used yeast cells to raise bread dough and to ferment alcoholic beverages, and bacterial cells to make cheeses and yogurts and as they bred thei
Throughout human history, we have learned a great deal about the different organisms that our ancestors used so effectively. The marked increase in our understanding of these organisms and their cell products gains us the ability to control the many functions of various cells and organisms. Using the techniques of gene splicing and recombinant DNA technology, we can now actually combine the genetic elements of two or more living cells. Functioning lengths of DNA can be taken from one organism and placed into the cells of another organism. As a result, for example, we can cause bacterial cells to produce human molecules. Cows can produce more milk for the same amount of feed. And we can synthesize therapeutic molecules that have never before existed. r strong, productive animals to make even stronger and more productive offspring.